Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice
Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although several studies have shown that social isolation stress during postweaning period induces behavioral and brain molecular changes, the effects of social isolation on behavior du...
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| Published in | Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 13 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2016
John Wiley & Sons, Inc Wiley |
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| Online Access | Get full text |
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| Abstract | Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although several studies have shown that social isolation stress during postweaning period induces behavioral and brain molecular changes, the effects of social isolation on behavior during adulthood have been less characterized. Aim of this work was to investigate the relationship between the behavioral alterations and brain molecular changes induced by chronic social isolation stress in adult male mice. Plasma corticosterone levels and adrenal glands weight were also analyzed. Socially isolated (SI) mice showed higher locomotor activity, spent less time in the open field center, and displayed higher immobility time in the tail suspension test compared to group-housed (GH) mice. SI mice exhibited reduced plasma corticosterone levels and reduced difference between right and left adrenal glands. SI showed lower mRNA levels of the BDNF-7 splice variant, c-Fos, Arc, and Egr-1 in both hippocampus and prefrontal cortex compared to GH mice. Finally, SI mice exhibited selectively reduced mGluR1 and mGluR2 levels in the prefrontal cortex. Altogether, these results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice. |
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| AbstractList | Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although several studies have shown that social isolation stress during postweaning period induces behavioral and brain molecular changes, the effects of social isolation on behavior during adulthood have been less characterized. Aim of this work was to investigate the relationship between the behavioral alterations and brain molecular changes induced by chronic social isolation stress in adult male mice. Plasma corticosterone levels and adrenal glands weight were also analyzed. Socially isolated (SI) mice showed higher locomotor activity, spent less time in the open field center, and displayed higher immobility time in the tail suspension test compared to group-housed (GH) mice. SI mice exhibited reduced plasma corticosterone levels and reduced difference between right and left adrenal glands. SI showed lower mRNA levels of the BDNF-7 splice variant, c-Fos, Arc, and Egr-1 in both hippocampus and prefrontal cortex compared to GH mice. Finally, SI mice exhibited selectively reduced mGluR1 and mGluR2 levels in the prefrontal cortex. Altogether, these results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice. Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although several studies have shown that social isolation stress during postweaning period induces behavioral and brain molecular changes, the effects of social isolation on behavior during adulthood have been less characterized. Aim of this work was to investigate the relationship between the behavioral alterations and brain molecular changes induced by chronic social isolation stress in adult male mice. Plasma corticosterone levels and adrenal glands weight were also analyzed. Socially isolated (SI) mice showed higher locomotor activity, spent less time in the open field center, and displayed higher immobility time in the tail suspension test compared to group-housed (GH) mice. SI mice exhibited reduced plasma corticosterone levels and reduced difference between right and left adrenal glands. SI showed lower mRNA levels of the BDNF-7 splice variant, c-Fos, Arc, and Egr-1 in both hippocampus and prefrontal cortex compared to GH mice. Finally, SI mice exhibited selectively reduced mGluR1 and mGluR2 levels in the prefrontal cortex. Altogether, these results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice.Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although several studies have shown that social isolation stress during postweaning period induces behavioral and brain molecular changes, the effects of social isolation on behavior during adulthood have been less characterized. Aim of this work was to investigate the relationship between the behavioral alterations and brain molecular changes induced by chronic social isolation stress in adult male mice. Plasma corticosterone levels and adrenal glands weight were also analyzed. Socially isolated (SI) mice showed higher locomotor activity, spent less time in the open field center, and displayed higher immobility time in the tail suspension test compared to group-housed (GH) mice. SI mice exhibited reduced plasma corticosterone levels and reduced difference between right and left adrenal glands. SI showed lower mRNA levels of the BDNF-7 splice variant, c-Fos, Arc, and Egr-1 in both hippocampus and prefrontal cortex compared to GH mice. Finally, SI mice exhibited selectively reduced mGluR1 and mGluR2 levels in the prefrontal cortex. Altogether, these results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice. |
| Audience | Academic |
| Author | Ieraci, Alessandro Popoli, Maurizio Mallei, Alessandra |
| AuthorAffiliation | Laboratorio di Neuropsicofarmacologia e Neurogenomica Funzionale, Dipartimento di Scienze Farmacologiche e Biomolecolari e Centro di Eccellenza sulle Malattie Neurodegenerative, Università di Milano, Milano, Italy |
| AuthorAffiliation_xml | – name: Laboratorio di Neuropsicofarmacologia e Neurogenomica Funzionale, Dipartimento di Scienze Farmacologiche e Biomolecolari e Centro di Eccellenza sulle Malattie Neurodegenerative, Università di Milano, Milano, Italy |
| Author_xml | – sequence: 1 fullname: Ieraci, Alessandro – sequence: 2 fullname: Popoli, Maurizio – sequence: 3 fullname: Mallei, Alessandra |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26881124$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2016 Alessandro Ieraci et al. COPYRIGHT 2016 John Wiley & Sons, Inc. Copyright © 2016 Alessandro Ieraci et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2016 Alessandro Ieraci et al. 2016 |
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| Issue | 2016 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Academic Editor: Jordan Marrocco |
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| PublicationTitle | Journal of neural transplantation & plasticity |
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| SubjectTerms | Adrenal glands Adrenal Glands - pathology Analysis Animals Anxiety Anxiety - etiology Anxiety - genetics Behavior Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Corticosterone Corticosterone - blood Cytoskeletal Proteins - metabolism Depression - etiology Depression - genetics Depression, Mental Early Growth Response Protein 1 - metabolism Genes Hippocampus - metabolism Male Mental depression Mental disorders Mice Mice, Inbred C57BL Nerve Tissue Proteins - metabolism Nervous system diseases Neuronal Plasticity - genetics Neuroplasticity Organ Size Prefrontal Cortex - metabolism Proteins Proto-Oncogene Proteins c-fos - metabolism RNA Social Isolation Stress Stress, Psychological - blood Stress, Psychological - complications Stress, Psychological - genetics Variance analysis |
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| Title | Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice |
| URI | https://search.emarefa.net/detail/BIM-1113215 https://dx.doi.org/10.1155/2016/6212983 https://www.ncbi.nlm.nih.gov/pubmed/26881124 https://www.proquest.com/docview/2407660882 https://www.proquest.com/docview/1765917425 https://pubmed.ncbi.nlm.nih.gov/PMC4736811 https://doaj.org/article/8c442ff28e4f4c38ae644932cf028166 |
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