Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound composed of capillary endothelial cells, glial cells,...

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Published inJournal of neural transplantation & plasticity Vol. 2018; no. 2018; pp. 1 - 13
Main Authors Hu, Wenyu, He, Zhiyi, Xin, Yanguo, Zhao, Yinan
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Animals
B cells
Blood-Brain Barrier - metabolism
Brain - metabolism
Brain Diseases - metabolism
Central nervous system
Communication
Connexins - metabolism
Endothelium
Humans
Lymphatic system
Nervous system
Nervous system diseases
Neuroglia - metabolism
Neurons
Neurons - metabolism
Permeability
Physiological aspects
Proteins
Review
Signal Transduction - physiology
Veins & arteries
China
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Abstract Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound composed of capillary endothelial cells, glial cells, pericytes, and neurons, which plays a pivotal role in maintaining the balance of the microenvironment in and out of the brain. Tight junctions and adherens junctions, which function as barriers of the blood-brain barrier, are two well-known kinds in the endothelial cell junctions. In this review, we focus on the less-concerned contribution of gap junction proteins, connexins in blood-brain barrier integrity under physio-/pathology conditions. In the neuro-glia-vascular unit, connexins are expressed in the capillary endothelial cells and prominent in astrocyte endfeet around and associated with maturation and function of the blood-brain barrier through a unique signaling pathway and an interaction with tight junction proteins. Connexin hemichannels and connexin gap junction channels contribute to the physiological or pathological progress of the blood-brain barrier; in addition, the interaction with other cell-cell-adhesive proteins is also associated with the maintenance of the blood-brain barrier. Lastly, we explore the connexins and connexin channels involved in the blood-brain barrier in neurological diseases and any programme for drug discovery or delivery to target or avoid the blood-brain barrier.
AbstractList Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a "neuro-glia-vascular unit," a structural and functional compound composed of capillary endothelial cells, glial cells, pericytes, and neurons, which plays a pivotal role in maintaining the balance of the microenvironment in and out of the brain. Tight junctions and adherens junctions, which function as barriers of the bloodbrain barrier, are two well-known kinds in the endothelial cell junctions. In this review, we focus on the less-concerned contribution of gap junction proteins, connexins in blood-brain barrier integrity under physio-/pathology conditions. In the neuro-glia-vascular unit, connexins are expressed in the capillary endothelial cells and prominent in astrocyte endfeet around and associated with maturation and function of the blood-brain barrier through a unique signaling pathway and an interaction with tight junction proteins. Connexin hemichannels and connexin gap junction channels contribute to the physiological or pathological progress of the blood-brain barrier; in addition, the interaction with other cell-cell-adhesive proteins is also associated with the maintenance of the blood-brain barrier. Lastly, we explore the connexins and connexin channels involved in the blood-brain barrier in neurological diseases and any programme for drug discovery or delivery to target or avoid the bloodbrain barrier.
Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain barrier is considered as a “neuro-glia-vascular unit,” a structural and functional compound composed of capillary endothelial cells, glial cells, pericytes, and neurons, which plays a pivotal role in maintaining the balance of the microenvironment in and out of the brain. Tight junctions and adherens junctions, which function as barriers of the blood-brain barrier, are two well-known kinds in the endothelial cell junctions. In this review, we focus on the less-concerned contribution of gap junction proteins, connexins in blood-brain barrier integrity under physio-/pathology conditions. In the neuro-glia-vascular unit, connexins are expressed in the capillary endothelial cells and prominent in astrocyte endfeet around and associated with maturation and function of the blood-brain barrier through a unique signaling pathway and an interaction with tight junction proteins. Connexin hemichannels and connexin gap junction channels contribute to the physiological or pathological progress of the blood-brain barrier; in addition, the interaction with other cell-cell-adhesive proteins is also associated with the maintenance of the blood-brain barrier. Lastly, we explore the connexins and connexin channels involved in the blood-brain barrier in neurological diseases and any programme for drug discovery or delivery to target or avoid the blood-brain barrier.
Audience Academic
Author Zhao, Yinan
He, Zhiyi
Hu, Wenyu
Xin, Yanguo
AuthorAffiliation 2 Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
1 Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
3 Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
AuthorAffiliation_xml – name: 2 Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
– name: 3 Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
– name: 1 Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
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Snippet Neuronal signaling together with synapse activity in the central nervous system requires a precisely regulated microenvironment. Recently, the blood-brain...
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SubjectTerms Animals
B cells
Blood-Brain Barrier - metabolism
Brain - metabolism
Brain Diseases - metabolism
Central nervous system
Communication
Connexins - metabolism
Endothelium
Humans
Lymphatic system
Nervous system
Nervous system diseases
Neuroglia - metabolism
Neurons
Neurons - metabolism
Permeability
Physiological aspects
Proteins
Review
Signal Transduction - physiology
Veins & arteries
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Title Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases
URI https://search.emarefa.net/detail/BIM-1210262
https://dx.doi.org/10.1155/2018/6323901
https://www.ncbi.nlm.nih.gov/pubmed/29983707
https://www.proquest.com/docview/2407661738
https://search.proquest.com/docview/2067132656
https://pubmed.ncbi.nlm.nih.gov/PMC6015683
https://doaj.org/article/c4e76b6f72b44ce59a4b903747ed154d
Volume 2018
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