An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

• Published in: Journal of Immunology Research Vol. 2018; no. 2018; pp. 1 - 22
• Main Authors: Chung, Wen-Hung, Hung, Shuen-Iu, Wang, Chuang-Wei, Pan, Ren-You, Abe, Riichiro, Chen, Chun-Bing, Tsai, Yi-Giien
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Allergic reaction; Allergies; Allergy; Analysis; Anaphylaxis; Animals; Antigen presentation; Antigen-antibody reactions; Antigens; Biomarkers, Pharmacological; Complications and side effects; Dermatitis; Dermatology; Drug allergy; Drug Eruptions - immunology; Drug Hypersensitivity - immunology; Enzymes; Eosinophilia; Ethnic Groups; Exanthema; Genetic diversity; Genotype; Haptens - immunology; Histocompatibility antigen HLA; Histocompatibility antigens; HLA Antigens - genetics; HLA histocompatibility antigens; Hospitals; Humans; Hypersensitivity; Immunology; Immunosuppressive agents; Ipilimumab; Lymphocytes; Medicine; Molecular modelling; Nonsteroidal anti-inflammatory drugs; Pharmacogenetics; Pharmacogenomics; Phenotypes; Polymorphism, Genetic; Receptors, Antigen, T-Cell - metabolism; Review; Risk; Risk factors; Side effects; Skin; T cell receptors; T cells; T-Lymphocytes - immunology; Toxic epidermal necrolysis; Urticaria; Urticaria - immunology; Taiwan

Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens–Johnson synd...