Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

• Published in: The Journal of clinical investigation Vol. 120; no. 3; pp. 924 - 930
• Main Authors: Bissig, Karl-Dimiter, Wieland, Stefan F., Tran, Phu, Isogawa, Masanori, Le, Tam T., Chisari, Francis V., Verma, Inder M.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.03.2010
• Subjects: Animal models in research; Animals; Antiviral agents; Biomedical research; Disease Models, Animal; Drug testing; Genetic aspects; Genomes; Health aspects; Hepacivirus; Hepatitis B; Hepatitis B - pathology; Hepatitis B - therapy; Hepatitis B - virology; Hepatitis B virus; Hepatitis C; Hepatitis C - pathology; Hepatitis C - therapy; Hepatitis C - virology; Hepatitis C virus; Hepatitis viruses; Hepatocytes - pathology; Hepatocytes - transplantation; Hepatocytes - virology; Humans; Infections; Liver - pathology; Liver - virology; Liver cancer; Mice; Mice, Knockout; Monkeys & apes; Pathogens; RNA polymerase; Technical Advance; Toxicity; Transplantation Chimera; Transplantation, Heterologous; Viral infections; Viruses; United States

A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has been an impediment to both furthering understanding of virus biology and testing antiviral therapies. We recently described a regulatable system for repopulating the liver of immunodeficie...