Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

• Published in: Nature medicine Vol. 22; no. 3; pp. 298 - 305
• Main Authors: Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V S K, Varambally, Sooryanarayana, Tomlins, Scott A, Nanus, David M, Tagawa, Scott T, Van Allen, Eliezer M, Elemento, Olivier, Sboner, Andrea, Garraway, Levi A, Rubin, Mark A, Demichelis, Francesca
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2016; Nature Publishing Group
• Subjects: 45/23; 45/91; 631/208/2489/2487/2486; 692/699/67/589/466; Adenocarcinoma - genetics; Adenocarcinoma - secondary; Aged; Aged, 80 and over; Analysis; Androgens; Biomedicine; Bone Neoplasms - genetics; Bone Neoplasms - secondary; Cancer Research; Care and treatment; Clonal Evolution - genetics; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic aspects; Health aspects; Hormone receptors; Humans; Infectious Diseases; letter; Liver Neoplasms - genetics; Liver Neoplasms - secondary; Male; Metabolic Diseases; Middle Aged; Molecular Medicine; Neuroendocrine Tumors - genetics; Neuroendocrine Tumors - secondary; Neurosciences; Patient outcomes; Physiological aspects; Prospective Studies; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - pathology; Receptors, Androgen - genetics; Retrospective Studies; United States
• ISSN: 1078-8956; 1546-170X; 1546-170X
• DOI: 10.1038/nm.4045

Genome-wide DNA methylation analysis of metastatic biopsies from patients with castration-resistant prostate cancer reveals marked epigenetic differences between samples with adenocarcinoma and neuroendocrine histologies. An increasingly recognized resistance mechanism to androgen receptor (AR)-dire...