Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

• Published in: PLoS pathogens Vol. 8; no. 6; p. e1002755
• Main Authors: Vulliez-Le Normand, Brigitte, Tonkin, Michelle L., Lamarque, Mauld H., Langer, Susann, Hoos, Sylviane, Roques, Magali, Saul, Frederick A., Faber, Bart W., Bentley, Graham A., Boulanger, Martin J., Lebrun, Maryse
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2012; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Animals; Antigens, Protozoan; Antigens, Protozoan - chemistry; Antigens, Protozoan - metabolism; Biochemistry, Molecular Biology; Biology; Cell Membrane; Cell Membrane - metabolism; Crystallization; Erythrocytes; Health aspects; Host-Parasite Interactions; Host-Parasite Interactions - physiology; Host-parasite relationships; Life Sciences; Malaria; Medical research; Membrane Proteins; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Microbiology and Parasitology; Models, Molecular; Molecular Sequence Data; Parasites; Parasitology; Physiological aspects; Plasmodium falciparum; Plasmodium falciparum - chemistry; Plasmodium falciparum - metabolism; Polymorphism, Genetic; Protein Binding; Protein Structure, Quaternary; Proteins; Protozoan Proteins; Protozoan Proteins - chemistry; Protozoan Proteins - metabolism; Structural Biology; Surface Plasmon Resonance; Vector-borne diseases; Virulence (Microbiology); France; Canada; Netherlands

Members of the phylum Apicomplexa, which include the malaria parasite Plasmodium, share many features in their invasion mechanism in spite of their diverse host cell specificities and life cycle characteristics. The formation of a moving junction (MJ) between the membranes of the invading apicomplex...