Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection

• Published in: PLoS pathogens Vol. 10; no. 7; p. e1004276
• Main Authors: Whitney, Paul G, Bär, Eva, Osorio, Fabiola, Rogers, Neil C, Schraml, Barbara U, Deddouche, Safia, LeibundGut-Landmann, Salomé, Reis e Sousa, Caetano
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2014; Public Library of Science (PLoS)
• Subjects: Animals; Biology and life sciences; Cancer; Candida albicans - immunology; Candidiasis - genetics; Candidiasis - immunology; Chemokines; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - pathology; Experiments; Fungal infections; Health aspects; Immunity, Innate; Interleukin-23 Subunit p19 - genetics; Interleukin-23 Subunit p19 - immunology; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - immunology; Kidneys; Kinases; Medical research; Mice; Mice, Knockout; Mortality; Mycoses; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - immunology; Physiological aspects; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - immunology; Rodents; Studies; Syk Kinase; T cells; United Kingdom; Switzerland

Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin receptors and MyD88-coupled toll-like receptors in myeloid cells, including neutrophils, macrophages and dendritic cells (DCs). Given the multitude of cell types and receptors involved, e...