Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

• Published in: Immunity (Cambridge, Mass.) Vol. 54; no. 2; pp. 225 - 234.e6
• Main Authors: Klawonn, Anna M., Fritz, Michael, Castany, Silvia, Pignatelli, Marco, Canal, Carla, Similä, Fredrik, Tejeda, Hugo A., Levinsson, Julia, Jaarola, Maarit, Jakobsson, Johan, Hidalgo, Juan, Heilig, Markus, Bonci, Antonello, Engblom, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.02.2021; Elsevier Limited
• Subjects: Affect (Psychology); Affective disorders; anhedonia; Aversion; Basic Medicine; Caudate-putamen; Cyclooxygenase-1; Cytokines; depression; DREADDs; Emotional behavior; Emotions; Excitability; Hedonic response; Immunologi inom det medicinska området; Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi); Immunology in the medical area; Immunology in the Medical Area (including Cell and Immunotherapy); Inactivation; Inflammation; Interleukin 6; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Mental depression; Mental disorders; Microglia; Modulation; Mood; Neostriatum; Nervous system; neuroinflammation; Neurological diseases; Neuromodulation; Neurons; prostaglandin; Signaling; Signs and symptoms; striatum; aversion; striatum; neuroinflammation; prostaglandin; anhedonia; DREADDs; depression; interleukin-6; Microglia

Microglia are activated in many neurological diseases and have been suggested to play an important role in the development of affective disorders including major depression. To investigate how microglial signaling regulates mood, we used bidirectional chemogenetic manipulations of microglial activit...