Production and applications of engineered viral capsids

• Published in: Applied microbiology and biotechnology Vol. 98; no. 13; pp. 5847 - 5858
• Main Authors: Glasgow, Jeff, Tullman-Ercek, Danielle
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2014; Springer Berlin Heidelberg; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biotechnology; Capsid; Capsid Proteins - genetics; Capsid Proteins - metabolism; chemistry; Drug therapy; drugs; Genetic aspects; Genetic engineering; Genomes; Hepatitis B; Infections; Life Sciences; medicine; Microbial Genetics and Genomics; Microbiology; Mini-Review; Mutation; Nanomedicine - methods; Nanoparticles; Nanotechnology; Nanotechnology - methods; Physiological aspects; Prevention; Proteins; Studies; Surface chemistry; therapeutics; Viral proteins; Virosomes - genetics; Virosomes - metabolism; Virus diseases; virus-like particles; Viruses; United States; United States > US; Viral capsids; Protein engineering; Targeted therapeutics; Virus-like particles; Nanotechnology

As biological agents, viruses come in an astounding range of sizes, with varied shapes and surface morphologies. The structures of viral capsids are generally assemblies of hundreds of copies of one or a few proteins which can be harnessed for use in a wide variety of applications in biotechnology,...