Targeted cytotoxic therapy kills persisting HIV infected cells during ART

• Published in: PLoS pathogens Vol. 10; no. 1; p. e1003872
• Main Authors: Denton, Paul W, Long, Julie M, Wietgrefe, Stephen W, Sykes, Craig, Spagnuolo, Rae Ann, Snyder, Olivia D, Perkey, Katherine, Archin, Nancie M, Choudhary, Shailesh K, Yang, Kuo, Hudgens, Michael G, Pastan, Ira, Haase, Ashley T, Kashuba, Angela D, Berger, Edward A, Margolis, David M, Garcia, J Victor
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2014; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; Anti-Retroviral Agents - immunology; Anti-Retroviral Agents - therapeutic use; Antiviral agents; Biology; Cell interaction; Dosage and administration; Drug therapy; HIV; HIV infection; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - immunology; HIV-1 - metabolism; Human immunodeficiency virus; Humans; Immunotoxins - immunology; Immunotoxins - pharmacology; Kinases; Medical research; Medicine; Mice; Mice, Inbred NOD; Mice, SCID; Microbiological research; Prevention; RNA, Viral - blood; RNA, Viral - immunology; United States

Antiretroviral therapy (ART) can reduce HIV levels in plasma to undetectable levels, but rather little is known about the effects of ART outside of the peripheral blood regarding persistent virus production in tissue reservoirs. Understanding the dynamics of ART-induced reductions in viral RNA (vRNA...