Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF

• Published in: PLoS pathogens Vol. 10; no. 2; p. e1003907
• Main Authors: Tunnicliffe, Richard B, Hautbergue, Guillaume M, Wilson, Stuart A, Kalra, Priti, Golovanov, Alexander P
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2014; Public Library of Science (PLoS)
• Subjects: Active Transport, Cell Nucleus - physiology; Binding proteins; Biology; Colleges & universities; Competition; Cytoplasm; Exports; Gene expression; Genetic aspects; Herpes; Herpes viruses; Herpesviridae Infections - metabolism; Herpesvirus 2, Saimiriine - chemistry; Herpesvirus 2, Saimiriine - metabolism; Herpesvirus 2, Saimiriine - pathogenicity; Herpesvirus diseases; Host-Parasite Interactions - physiology; Humans; Medicine; Messenger RNA; Nuclear Proteins - chemistry; Nuclear Proteins - metabolism; Physiological aspects; Protein Structure, Quaternary; Proteins; Repressor Proteins - chemistry; Repressor Proteins - metabolism; RNA Transport - physiology; RNA, Viral - analysis; RNA, Viral - metabolism; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - metabolism; Software; Trans-Activators - chemistry; Trans-Activators - metabolism; Transcription Factors - chemistry; Transcription Factors - metabolism; Tumor Virus Infections - metabolism; RNA Transport; Tumor Virus Infections; Herpesvirus 2, Saimiriine; Humans; Repressor Proteins; Trans-Activators; RNA-Binding Proteins; Nuclear Proteins; Herpesviridae Infections; RNA, Viral; Protein Structure, Quaternary; Transcription Factors; Active Transport, Cell Nucleus; Host-Parasite Interactions

The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery. ORF57 protein specifically recognizes viral mRNA transcripts, and binds to proteins of the cellular transcription-export (TR...