Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants

• Published in: PLoS pathogens Vol. 13; no. 5; p. e1006402
• Main Authors: Introini, Andrea, Boström, Stéphanie, Bradley, Frideborg, Gibbs, Anna, Glaessgen, Axel, Tjernlund, Annelie, Broliden, Kristina
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2017; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Biology and Life Sciences; CCL20 protein; CCR5 protein; Cervix; Cervix uteri; Cervix Uteri - immunology; Cervix Uteri - virology; Chemokine CCL1 - genetics; Chemokine CCL1 - immunology; Chemokine CCL20 - genetics; Chemokine CCL20 - immunology; Conditioning; Deoxyribonucleic acid; Disease prevention; Disease transmission; DNA; Electrochemical machining; Explants; Exposure; Female; Gene expression; Growth factors; Health aspects; HIV; HIV Infections - immunology; HIV Infections - transmission; HIV Infections - virology; HIV-1 - genetics; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immunoregulation; In Vitro Techniques; Infections; Infectious diseases; Inflammation; Inflammatory response; Interleukin 1; Interleukin 6; Interleukin 7; Interleukin-6 - genetics; Interleukin-6 - immunology; Leukocytes; Leukocytes (neutrophilic); Male; Mathematical analysis; Mathematical models; Medicine; Medicine and Health Sciences; Middle Aged; Monocytes; Mucosa; Neutrophils; Peripheral blood; Plasma; Polymerase chain reaction; Recruitment; Replication; Rodents; Semen; Semen - immunology; Sexual intercourse; Social Sciences; Tumor necrosis factor; Uterus; Virology; Virus Replication; Viruses

The most immediate and evident effect of mucosal exposure to semen in vivo is a local release of proinflammatory mediators accompanied by an influx of leukocytes into the female genital mucosa (FGM). The implication of such response in HIV-1 transmission has never been addressed due to limitations o...