Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

• Published in: Diabetes care Vol. 41; no. 8; pp. 1732 - 1739
• Main Authors: Luukkonen, Panu K., Sädevirta, Sanja, Zhou, You, Kayser, Brandon, Ali, Ashfaq, Ahonen, Linda, Lallukka, Susanna, Pelloux, Véronique, Gaggini, Melania, Jian, Ching, Hakkarainen, Antti, Lundbom, Nina, Gylling, Helena, Salonen, Anne, Orešič, Matej, Hyötyläinen, Tuulia, Orho-Melander, Marju, Rissanen, Aila, Gastaldelli, Amalia, Clément, Karine, Hodson, Leanne, Yki-Järvinen, Hannele
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.08.2018
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Adult; blood; Body mass; Body weight; body weight gain; carbohydrate metabolism; Carbohydrate Metabolism - physiology; Cardiovascular diseases; ceramide derivative; clinical article; Clinical Medicine; clinical trial; complication; Composition; Conference Paper; controlled study; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diet; Dietary Fats, Unsaturated; Dietary Fats, Unsaturated - adverse effects; Dietary Fats, Unsaturated - metabolism; dietary intake; edible oil; Endocrinology and Diabetes; Endokrinologi och diabetes; Endotoxemia; fatty acid; Fatty Acids; Fatty Acids - adverse effects; Fatty Acids - metabolism; Fatty liver; feeding behavior; Feeding Behavior - physiology; Female; food composition; Gene expression; Glycerol; Health hazards; Health risks; high calorie diet; human; Humans; Hyperinsulinemia; Insulin; Insulin - metabolism; Insulin Resistance; Klinisk medicin; Life Sciences; lipid blood level; lipid metabolism; Lipid Metabolism - physiology; Lipogenesis; Lipolysis; Liver; Liver - metabolism; Liver diseases; macronutrient; Male; Medical and Health Sciences; Medicin och hälsovetenskap; metabolism; Middle Aged; monosaccharide; Monosaccharides; Monosaccharides - adverse effects; Monosaccharides - metabolism; Non-alcoholic Fatty Liver Disease; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; nonalcoholic fatty liver; obesity; Oils & fats; Overweight; Overweight - complications; Overweight - metabolism; Pathophysiology/Complications; physiology; proton nuclear magnetic resonance; Research design; saturated fatty acid; Sugar; triacylglycerol; Triglycerides; Triglycerides - blood; unsaturated fatty acid; Weight Gain

Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrien...