An Involvement of Granulocyte Medullasin in Phenytoin-Induced Gingival Overgrowth in Rats

To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet contai...

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Published inJapanese Journal of Pharmacology Vol. 89; no. 3; pp. 235 - 241
Main Authors Ozaki, Yukio, Kunimatsu, Kazushi, Hara, Yoshitaka, Kato, Ihachi, Aoki, Yosuke, Yamamoto, Kenji, Kato, Yuzo
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 2002
Subjects
Animals
Gingiva - chemistry
Gingiva - drug effects
Gingiva - metabolism
Gingival Hyperplasia - chemically induced
Gingival Hyperplasia - metabolism
Gingival overgrowth
Granulocytes - chemistry
Granulocytes - drug effects
Granulocytes - metabolism
Immunohistochemistry
Male
Medullasin
Phenytoin
Phenytoin - pharmacology
Rats
Rats, Inbred F344
Serine Endopeptidases - analysis
Serine Endopeptidases - biosynthesis
Serine proteinase
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Abstract To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1, 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immuno-histochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-like cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.
AbstractList To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1, 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immunohistochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-like cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.
To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1, 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immuno-histochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-like cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.
To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1 , 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immunohistochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-1ike cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.
Author Hara, Yoshitaka
Yamamoto, Kenji
Aoki, Yosuke
Kato, Yuzo
Kato, Ihachi
Ozaki, Yukio
Kunimatsu, Kazushi
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Snippet To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in...
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SubjectTerms Animals
Gingiva - chemistry
Gingiva - drug effects
Gingiva - metabolism
Gingival Hyperplasia - chemically induced
Gingival Hyperplasia - metabolism
Gingival overgrowth
Granulocytes - chemistry
Granulocytes - drug effects
Granulocytes - metabolism
Immunohistochemistry
Male
Medullasin
Phenytoin
Phenytoin - pharmacology
Rats
Rats, Inbred F344
Serine Endopeptidases - analysis
Serine Endopeptidases - biosynthesis
Serine proteinase
Title An Involvement of Granulocyte Medullasin in Phenytoin-Induced Gingival Overgrowth in Rats
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https://www.jstage.jst.go.jp/article/jjp/89/3/89_3_235/_article/-char/en
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https://www.ncbi.nlm.nih.gov/pubmed/12184728
Volume 89
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