A Reaction-Diffusion Model of Human Brain Development

• Published in: PLoS computational biology Vol. 6; no. 4; p. e1000749
• Main Authors: Lefèvre, Julien, Mangin, Jean-François
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2010; Public Library of Science (PLoS)
• Subjects: Algorithms; Brain; Cerebral Cortex - growth & development; Computer Simulation; Developmental Biology/Pattern Formation; Experiments; Gene expression; Genetic aspects; Growth; Humans; Hypotheses; Mathematics; Models, Neurological; Models, Statistical; Neuroscience/Neurodevelopment; Physiological aspects; Protein folding; Reproducibility of Results; Studies; France; Reproducibility of Results; Algorithms; Computer Simulation; Humans; Cerebral Cortex; Models, Neurological; Models, Statistical

Cortical folding exhibits both reproducibility and variability in the geometry and topology of its patterns. These two properties are obviously the result of the brain development that goes through local cellular and molecular interactions which have important consequences on the global shape of the...