Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects

• Published in: European journal of clinical nutrition Vol. 64; no. 4; pp. 424 - 431
• Main Authors: Jauhiainen, T, Ronnback, M, Vapaatalo, H, Wuolle, K, Kautiainen, H, Groop, P.H, Korpela, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2010; Nature Publishing Group
• Subjects: 692/699/75/243; 692/700/139/1735; 692/700/565/2072; Adult; Animals; Antihypertensive Agents; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Arterial hypertension. Arterial hypotension; arterial stiffness; arteries; Atherosclerosis; bioactive properties; Biological and medical sciences; Blood and lymphatic vessels; Blood pressure; Blood Pressure - drug effects; Cardiology. Vascular system; Caseins; Caseins - chemistry; Caseins - metabolism; Chemical properties; chemistry; Clinical Nutrition; Complications and side effects; Composition; Diet therapy; dose response; Dose-response effects; Double-Blind Method; drug effects; drug therapy; endothelium; Endothelium, Vascular; Endothelium, Vascular - drug effects; Epidemiology; Feeding. Feeding behavior; Female; Fermentation; fermented milk; Food Microbiology; Fundamental and applied biological sciences. Psychology; Health aspects; human diseases; human nutrition; Humans; Hypertension; Hypertension - drug therapy; Hypertension - metabolism; Inhalation; Internal Medicine; Intervention; isoleucine; Lactobacillus; Lactobacillus helveticus; long term experiments; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; metabolism; microbiology; Middle Aged; Milk; Milk - chemistry; Milk - metabolism; Milk - microbiology; Nutrition research; nutritional intervention; Oligopeptides; Oligopeptides - pharmacology; Oligopeptides - therapeutic use; Original; original-article; patients; Peptides; pharmacology; Pressure measurement; Prevention; Probiotics; proline; Public Health; Radial Artery; Risk factors; therapeutic use; tripeptides; valine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Wave analysis; Finland; arterial stiffness; endothelial function; bioactive peptides; aortic augmentation index; hypertension; pulse wave analysis; Human; Hypertension; Lactobacillus helveticus; Peptides; Cardiovascular disease; Metabolic diseases; Increase; Long term; Artery; Endothelium; Blood vessel; Bacteria; Lactobacillaceae; Aorta; Stiffness; Circulatory system; Cultured milk

Background: The milk casein-derived biologically active tripeptides, isoleucyl-prolyl-proline (Ile-Pro-Pro) and valyl-prolyl-proline (Val-Pro-Pro), have documented antihypertensive effect probably related to reduced angiotensin formation. It has been suggested that these tripeptides may reduce arter...