Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors

• Published in: PLoS genetics Vol. 9; no. 6; p. e1003555
• Main Authors: Cho, Kyoung-In, Haque, Mdemdadul, Wang, Jessica, Yu, Minzhong, Hao, Ying, Qiu, Sunny, Pillai, Indulekha C L, Peachey, Neal S, Ferreira, Paulo A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2013; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Biology; Cell death; Cell Death - genetics; Cell Lineage; Colleges & universities; Degeneration; Gene expression; Genetic aspects; Health aspects; Health sciences; Humans; Light; Mice; Mice, Transgenic; Microscopy; Molecular Chaperones - genetics; Nerve Net - metabolism; Nervous system; Neural networks; Neurodegeneration; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Nuclear Pore Complex Proteins - genetics; Photoreceptors; Physiological aspects; Proteins; Retina - metabolism; Retina - pathology; Retinal Cone Photoreceptor Cells - metabolism; Retinal Cone Photoreceptor Cells - pathology; Retinal Degeneration - genetics; Retinal Degeneration - pathology; Retinal Rod Photoreceptor Cells - cytology; Retinal Rod Photoreceptor Cells - metabolism; Up-Regulation; United States

Non-autonomous cell-death is a cardinal feature of the disintegration of neural networks in neurodegenerative diseases, but the molecular bases of this process are poorly understood. The neural retina comprises a mosaic of rod and cone photoreceptors. Cone and rod photoreceptors degenerate upon rod-...