A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility

• Published in: EBioMedicine Vol. 55; p. 102766
• Main Authors: Wei, Meilin, Huang, Fengjie, Zhao, Ling, Zhang, Yunjing, Yang, Wei, Wang, Shouli, Li, Mengci, Han, Xiaolong, Ge, Kun, Qu, Chun, Rajani, Cynthia, Xie, Guoxiang, Zheng, Xiaojiao, Zhao, Aihua, Bian, Zhaoxiang, Jia, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2020; Elsevier
• Subjects: Adipose Tissue, Brown - metabolism; Advanced Basic Science; Animals; Bile acids; Body Mass Index; Chenodeoxycholic Acid - metabolism; Cholestenones - metabolism; Clostridiales - metabolism; Clostridiales - pathogenicity; Cohort Studies; Diet, High-Fat - adverse effects; Disease Models, Animal; Disease Susceptibility; Energy expenditure; Gastrointestinal Microbiome; Gene Expression Regulation; GLP-1; Glucagon-Like Peptide 1 - genetics; Glucagon-Like Peptide 1 - metabolism; Gut microbiota; Humans; Ileum - metabolism; Ileum - microbiology; Internal Medicine; Lithocholic Acid - metabolism; Male; Metagenomics - methods; Mice; Mice, Inbred C57BL; Obesity; Obesity - etiology; Obesity - genetics; Obesity - metabolism; Obesity - microbiology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Research paper; UCP1; Uncoupling Protein 1 - genetics; Uncoupling Protein 1 - metabolism; Ursodeoxycholic Acid - metabolism; Gut microbiota; Energy expenditure; UCP1; Obesity; Bile acids; GLP-1

The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. We investigated BA composition of high BMI subjects...