Regulation of Mutagenic DNA Polymerase V Activation in Space and Time

• Published in: PLoS genetics Vol. 11; no. 8; p. e1005482
• Main Authors: Robinson, Andrew, McDonald, John P., Caldas, Victor E. A., Patel, Meghna, Wood, Elizabeth A., Punter, Christiaan M., Ghodke, Harshad, Cox, Michael M., Woodgate, Roger, Goodman, Myron F., van Oijen, Antoine M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2015; Public Library of Science (PLoS)
• Subjects: Bacteria; Chromosomes; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - genetics; DNA polymerase; DNA polymerases; DNA repair; DNA Replication - genetics; DNA, Bacterial - genetics; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; DNA-Directed DNA Polymerase - radiation effects; E coli; Enzyme Activation - genetics; Enzymes; Escherichia coli; Escherichia coli - genetics; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Escherichia coli Proteins - radiation effects; Funding; Gene Expression Regulation, Bacterial - genetics; Genetic aspects; Genetic regulation; Glucose; Light; Localization; Mutagenesis; Mutation; Observations; Physiological aspects; Protein Processing, Post-Translational - genetics; Rec A Recombinases - genetics; RecA protein; Regulation; SOS Response, Genetics - genetics; Transcription, Genetic - genetics; Ultraviolet Rays

Spatial regulation is often encountered as a component of multi-tiered regulatory systems in eukaryotes, where processes are readily segregated by organelle boundaries. Well-characterized examples of spatial regulation are less common in bacteria. Low-fidelity DNA polymerase V (UmuD'2C) is prod...