A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

• Published in: Cancer letters Vol. 382; no. 2; pp. 203 - 214
• Main Authors: Jia, Dongyu, Liu, Zhenqiu, Deng, Nan, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Taylor-Harding, Barbie, Cheon, Dong-Joo, Lawrenson, Kate, Wiedemeyer, Wolf R., Walts, Ann E., Karlan, Beth Y., Orsulic, Sandra
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.11.2016; Elsevier Limited
• Subjects: Actins - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Cancer-associated fibroblasts; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Clinical outcomes; Coculture Techniques; Collagen; Collagen Type I - genetics; Collagen Type I - metabolism; Collagen Type I, alpha 1 Chain; Cytokines; Databases, Genetic; Disease-Free Survival; Drug resistance; Enzymes; Fibroblasts; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genes; Growth factors; Hematology, Oncology and Palliative Medicine; Humans; Hybridization; Kaplan-Meier Estimate; Medical research; Metastasis; Mutation; Myofibroblasts; Myofibroblasts - metabolism; Myofibroblasts - pathology; Neoplasm Grading; Neoplasm Staging; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - metabolism; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - therapy; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ovarian Neoplasms - therapy; Pan-cancer; Pancreatic cancer; Smooth muscle; Therapeutic targets; Time Factors; Toxicity; Transcriptome; Tumor Microenvironment; Womens health; Tumor microenvironment; Pan-cancer; TNC; EMT; ECM; Therapeutic targets; Cancer-associated fibroblasts; PDGFRα; CAFs; LOX; FAP; PALLD; PDPN; αSMA; TGFβ; CSPG4; Myofibroblasts; PRECOG; α-smooth muscle actin; transforming growth factor β; fibroblast activation protein; podoplanin; palladin; PREdiction of Clinical Outcomes from Genomic Profiles; platelet-derived growth factor receptor α; epithelial–mesenchymal transition; tenascin-C; lysyl oxidase; chondroitin sulfate proteoglycan 4; extracellular matrix

•COL11A1 is a highly specific biomarker of activated CAFs in multiple epithelial cancer types.•COL11A1 is not expressed in mesenchymal precursors and fibroblasts associated with inflammation and organ fibrosis.•Activated CAFs across genetically different epithelial cancer types express a highly cons...