A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus
In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains incl...
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Published in | PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES Vol. 367; no. 1598; pp. 2023 - 2032 |
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Main Authors | , |
Format | Journal Article Publication |
Language | English |
Published |
England
The Royal Society
19.07.2012
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Subjects | |
Online Access | Get full text |
ISSN | 0962-8436 1471-2970 1471-2970 |
DOI | 10.1098/rstb.2012.0009 |
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Abstract | In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC. |
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AbstractList | In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC. In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC. |
Author | Uddén, Julia Bahlmann, Jörg |
AuthorAffiliation | 1 Max Planck Institute for Psycholinguistics , Nijmegen , The Netherlands 2 Department of Clinical Neuroscience , Stockholm Brain Institute , Karolinska Institute , Stockholm , Sweden 4 Helen Wills Neuroscience Institute , University of California at Berkeley , Berkeley, CA , USA 5 Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany 3 Centre for Cognitive Neuroimaging , Donders Institute for Brain, Cognition and Behaviour , Radboud University Nijmegen , Nijmegen , The Netherlands |
AuthorAffiliation_xml | – name: 5 Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany – name: 4 Helen Wills Neuroscience Institute , University of California at Berkeley , Berkeley, CA , USA – name: 2 Department of Clinical Neuroscience , Stockholm Brain Institute , Karolinska Institute , Stockholm , Sweden – name: 3 Centre for Cognitive Neuroimaging , Donders Institute for Brain, Cognition and Behaviour , Radboud University Nijmegen , Nijmegen , The Netherlands – name: 1 Max Planck Institute for Psycholinguistics , Nijmegen , The Netherlands |
Author_xml | – sequence: 1 givenname: Julia surname: Uddén fullname: Uddén, Julia email: julia.udden@mpi.nl organization: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands – sequence: 2 givenname: Jörg surname: Bahlmann fullname: Bahlmann, Jörg organization: Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22688637$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:$$DView record from Swedish Publication Index |
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Snippet | In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective... |
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SubjectTerms | Behavioral neuroscience Brain - physiology Brocas area Cognition Cognitive Control Connectivity Humans Inferior Frontal Gyrus Language Lateral Prefrontal Cortex Magnetic resonance imaging Music Musical forms Musical grammar Nerve Net - physiology Neuroimaging - methods Parahippocampal Gyrus - anatomy & histology Parahippocampal Gyrus - physiology Phonology Prefrontal cortex Prefrontal Cortex - anatomy & histology Prefrontal Cortex - physiology Psychomotor Performance - physiology Reaction Time Review Semantics Sequence Processing Syntactics Transcranial Magnetic Stimulation |
Title | A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus |
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