A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus

In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains incl...

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Published inPHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES Vol. 367; no. 1598; pp. 2023 - 2032
Main Authors Uddén, Julia, Bahlmann, Jörg
Format Journal Article Publication
LanguageEnglish
Published England The Royal Society 19.07.2012
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ISSN0962-8436
1471-2970
1471-2970
DOI10.1098/rstb.2012.0009

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Abstract In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.
AbstractList In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.
In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.
Author Uddén, Julia
Bahlmann, Jörg
AuthorAffiliation 1 Max Planck Institute for Psycholinguistics , Nijmegen , The Netherlands
2 Department of Clinical Neuroscience , Stockholm Brain Institute , Karolinska Institute , Stockholm , Sweden
4 Helen Wills Neuroscience Institute , University of California at Berkeley , Berkeley, CA , USA
5 Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany
3 Centre for Cognitive Neuroimaging , Donders Institute for Brain, Cognition and Behaviour , Radboud University Nijmegen , Nijmegen , The Netherlands
AuthorAffiliation_xml – name: 5 Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany
– name: 4 Helen Wills Neuroscience Institute , University of California at Berkeley , Berkeley, CA , USA
– name: 2 Department of Clinical Neuroscience , Stockholm Brain Institute , Karolinska Institute , Stockholm , Sweden
– name: 3 Centre for Cognitive Neuroimaging , Donders Institute for Brain, Cognition and Behaviour , Radboud University Nijmegen , Nijmegen , The Netherlands
– name: 1 Max Planck Institute for Psycholinguistics , Nijmegen , The Netherlands
Author_xml – sequence: 1
  givenname: Julia
  surname: Uddén
  fullname: Uddén, Julia
  email: julia.udden@mpi.nl
  organization: Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
– sequence: 2
  givenname: Jörg
  surname: Bahlmann
  fullname: Bahlmann, Jörg
  organization: Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA
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SSID ssj0009574
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SecondaryResourceType review_article
Snippet In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective...
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SourceType Open Access Repository
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StartPage 2023
SubjectTerms Behavioral neuroscience
Brain - physiology
Brocas area
Cognition
Cognitive Control
Connectivity
Humans
Inferior Frontal Gyrus
Language
Lateral Prefrontal Cortex
Magnetic resonance imaging
Music
Musical forms
Musical grammar
Nerve Net - physiology
Neuroimaging - methods
Parahippocampal Gyrus - anatomy & histology
Parahippocampal Gyrus - physiology
Phonology
Prefrontal cortex
Prefrontal Cortex - anatomy & histology
Prefrontal Cortex - physiology
Psychomotor Performance - physiology
Reaction Time
Review
Semantics
Sequence Processing
Syntactics
Transcranial Magnetic Stimulation
Title A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus
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https://www.jstor.org/stable/23250431
https://royalsocietypublishing.org/doi/full/10.1098/rstb.2012.0009
https://www.ncbi.nlm.nih.gov/pubmed/22688637
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https://pubmed.ncbi.nlm.nih.gov/PMC3367683
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Volume 367
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