Highly Frequent Mutations in Negative Regulators of Multiple Virulence Genes in Group A Streptococcal Toxic Shock Syndrome Isolates

• Published in: PLoS pathogens Vol. 6; no. 4; p. e1000832
• Main Authors: Ikebe, Tadayoshi, Ato, Manabu, Matsumura, Takayuki, Hasegawa, Hideki, Sata, Tetsutaro, Kobayashi, Kazuo, Watanabe, Haruo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2010; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amino acids; Animals; Bacterial Proteins - genetics; Bacteriology; Blotting, Western; Child; Child, Preschool; Comparative Genomic Hybridization; Gene Expression; Gene Expression Regulation, Viral; Gene mutations; Genes; Genetic aspects; Genetic research; Genetics and Genomics/Disease Models; Genetics and Genomics/Genetics of Disease; Health aspects; Humans; Infant; Infant, Newborn; Infectious Diseases/Bacterial Infections; Male; Mice; Mice, Nude; Microbiology/Medical Microbiology; Middle Aged; Mortality; Mutation; Protein Kinases - genetics; Proteins; Repressor Proteins - genetics; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Shock, Septic - genetics; Streptococcal Infections - genetics; Streptococcus pyogenes - genetics; Streptococcus pyogenes - pathogenicity; Studies; Toxic shock syndrome; Trans-Activators - genetics; Virulence; Virulence Factors - biosynthesis; Virulence Factors - genetics; Young Adult; Japan

Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock and multiorgan failure; it has a high mortality rate. Although a number of studies have attempted to determine the crucial factors behind the onset of STSS, the responsible genes in gr...