A molecular atlas of cell types and zonation in the brain vasculature

• Published in: Nature (London) Vol. 554; no. 7693; pp. 475 - 480
• Main Authors: Vanlandewijck, Michael, He, Liqun, Mäe, Maarja Andaloussi, Andrae, Johanna, Ando, Koji, Del Gaudio, Francesca, Nahar, Khayrun, Lebouvier, Thibaud, Laviña, Bàrbara, Gouveia, Leonor, Sun, Ying, Raschperger, Elisabeth, Räsänen, Markus, Zarb, Yvette, Mochizuki, Naoki, Keller, Annika, Lendahl, Urban, Betsholtz, Christer
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2018; Nature Publishing Group
• Subjects: 13; 13/1; 38/39; 631/378/1341; 692/698/1688/64; Alzheimer's disease; Animals; Arteries - cytology; Arterioles - cytology; Blood Vessels - cytology; Blood-brain barrier; Brain; Brain - blood supply; Brain - cytology; Brain cells; Brain mapping; Brain research; Capillaries; Capillaries - cytology; Cell adhesion & migration; Developed countries; Encyclopedias; Endothelial cells; Endothelial Cells - classification; Female; Fibroblasts; Fibroblasts - classification; Gene expression; Humanities and Social Sciences; Identification and classification; Male; Methods; Mice; multidisciplinary; Myocytes, Smooth Muscle - classification; Organ Specificity; Pericytes - classification; RNA sequencing; Science; Single-Cell Analysis; Specialization; Transcription; Transcriptome; Veins & arteries; Veins - cytology; Zonation

Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular an...