RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility

• Published in: PLoS genetics Vol. 9; no. 7; p. e1003628
• Main Authors: O'Bryan, Moira K., Clark, Brett J., McLaughlin, Eileen A., D'Sylva, Rebecca J., O'Donnell, Liza, Wilce, Jacqueline A., Sutherland, Jessie, O'Connor, Anne E., Whittle, Belinda, Goodnow, Christopher C., Ormandy, Christopher J., Jamsai, Duangporn
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2013; Public Library of Science (PLoS)
• Subjects: Alternative Splicing - genetics; Animals; Biology; Cancer; Cell adhesion & migration; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - genetics; Cell differentiation; Cell Differentiation - genetics; Councils; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; Fertility, Human; Gene expression; Genetic aspects; Genetic engineering; Germ cells; Germ Cells - pathology; Humans; Infertility; Infertility, Male - genetics; Infertility, Male - pathology; Male; Mass spectrometry; Mice; Models, Molecular; Mutation; Nucleotide Motifs - genetics; Physiological aspects; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - genetics; Rodents; Signal transduction; Sperm; Spermatids - metabolism; Spermatids - pathology; Tumor Suppressor Proteins - chemistry; Tumor Suppressor Proteins - genetics; Australia

Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation is associated with many human diseases; however, k...