Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies

• Published in: EBioMedicine Vol. 25; no. C; pp. 32 - 40
• Main Authors: Xie, Yuan-Hong, Gao, Qin-Yan, Cai, Guo-Xiang, Sun, Xiao-Ming, Zou, Tian-Hui, Chen, Hui-Min, Yu, Si-Yi, Qiu, Yi-Wen, Gu, Wei-Qi, Chen, Xiao-Yu, Cui, Yun, Sun, Danfeng, Liu, Zhan-Ju, Cai, San-Jun, Xu, Jie, Chen, Ying-Xuan, Fang, Jing-Yuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017; Elsevier
• Subjects: Adult; Advanced Basic Science; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Biomarkers, Tumor - isolation & purification; Clostridium symbiosum; Clostridium symbiosum - genetics; Clostridium symbiosum - isolation & purification; Colonoscopy; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Early Detection of Cancer; Early diagnosis; Feces - microbiology; Female; Fusobacterium nucleatum - genetics; Fusobacterium nucleatum - isolation & purification; Gastrointestinal Microbiome - genetics; Humans; Internal Medicine; Male; Middle Aged; Occult Blood; Predictive Value of Tests; Quantitative PCR; Research Paper; Clostridium symbiosum; Early diagnosis; Quantitative PCR; Colorectal cancer

Current non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for early and advanced colorectal cancer detection. In the test stage, the relative abundance of Clostridium symbiosum (C. symbiosum) was measure...