Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations

• Published in: PLoS genetics Vol. 9; no. 8; p. e1003678
• Main Authors: Absher, Devin M., Li, Xinrui, Waite, Lindsay L., Gibson, Andrew, Roberts, Kevin, Edberg, Jeffrey, Chatham, W. Winn, Kimberly, Robert P.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2013; Public Library of Science (PLoS)
• Subjects: Antigens, CD19 - metabolism; Autoimmune diseases; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biology; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell Lineage; CpG Islands - genetics; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; DNA sequencing; Epigenetics; Epigenomics; Genetic aspects; Genome, Human; Genome-wide association studies; Health aspects; Humans; Interferon; Interferons - genetics; Interferons - immunology; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Medicine; Methylation; Nucleotide sequencing; Physiological aspects; Promoter Regions, Genetic; Systemic lupus erythematosus; T cells; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; United States

Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic, epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we collected CD4+ T-cells, CD19+ B-cells, and CD14+ monocytes from 49 SLE patients and 58 controls, and performed genome-wide DNA...