Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations - Absher, Devin M.; Li, Xinrui; Waite, Lindsay L.; Gibson, Andrew; Roberts, Kevin; Edberg, Jeffrey; Chatham, W. Winn; Kimberly, Robert P. (PLoS genetics, 2013)
Keywords: Antigens, CD19 - metabolism; Autoimmune diseases; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biology; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell Lineage; CpG Islands - genetics; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; DNA sequencing; Epigenetics; Epigenomics; Genetic aspects; Genome, Human; Genome-wide association studies; Health aspects; Humans; Interferon; Interferons - genetics; Interferons - immunology; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Medicine; Methylation; Nucleotide sequencing; Physiological aspects; Promoter Regions, Genetic; Systemic lupus erythematosus; T cells; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; United States