Mutation of Npr2 Leads to Blurred Tonotopic Organization of Central Auditory Circuits in Mice

• Published in: PLoS genetics Vol. 10; no. 12; p. e1004823
• Main Authors: Lu, Cindy C., Cao, Xiao-Jie, Wright, Samantha, Ma, Le, Oertel, Donata, Goodrich, Lisa V.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2014; Public Library of Science (PLoS)
• Subjects: Acoustic nerve; Action Potentials; Animals; Auditory Pathways - abnormalities; Auditory Pathways - embryology; Auditory Pathways - metabolism; Auditory Perception - physiology; Axons - physiology; Biology and Life Sciences; Body Patterning - genetics; Brain Stem - abnormalities; Brain Stem - cytology; Brain Stem - pathology; Cochlea - abnormalities; Cochlea - cytology; Cochlea - pathology; Cochlear Nerve - abnormalities; Cochlear Nerve - embryology; Cochlear Nerve - pathology; Colleges & universities; Ears & hearing; Embryo, Mammalian; Female; Gene mutations; Genetic aspects; Genetic research; Mice; Mice, Transgenic; Mutation; Neural circuitry; Neurological research; Neurons, Afferent - physiology; Neurosciences; Pregnancy; Receptors, Atrial Natriuretic Factor - genetics; Rodents

Tonotopy is a fundamental organizational feature of the auditory system. Sounds are encoded by the spatial and temporal patterns of electrical activity in spiral ganglion neurons (SGNs) and are transmitted via tonotopically ordered processes from the cochlea through the eighth nerve to the cochlear...