Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons

• Published in: Science (American Association for the Advancement of Science) Vol. 291; no. 5512; pp. 2419 - 2423
• Main Authors: Kohara, Keigo, Kitamura, Akihiko, Morishima, Mieko, Tsumoto, Tadaharu
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 23.03.2001; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Animals; Animals, Newborn; Antibodies; Axonal Transport; Axons; Axons - metabolism; Biological and medical sciences; Brain; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cell Nucleus - metabolism; Cells, Cultured; Cerebral cortex; Complementary DNA; Dendrites - metabolism; Deoxyribonucleic acid; DNA; DNA, Complementary; Fluorescence; Fundamental and applied biological sciences. Psychology; Immunohistochemistry; Isolated neuron and nerve. Neuroglia; Luminescent Proteins - metabolism; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins - analysis; Microtubule-Associated Proteins - immunology; Nerve growth factor; Neurites; Neurites - metabolism; Neurology; Neuronal Plasticity; Neurons; Neurons - drug effects; Neurons - metabolism; Neuroscience; Plasmids; Protein Transport; Proteins; Recombinant Fusion Proteins - metabolism; Superposition principle; Synapses - metabolism; tau Proteins - analysis; tau Proteins - immunology; Tetrodotoxin - pharmacology; Vertebrates: nervous system and sense organs; Visual Cortex - cytology; Japan; Neurotrophin; Cerebral cortex; Electrical activity; Rodentia; Central nervous system; Electrophysiology; In vitro; Neurotrophic factor; Vertebrata; Mammalia; Mouse; Axoplasmic transport; Plasticity; Transfer; Postsynaptic neuron; Brain derived neurotrophic factor; Brain (vertebrata); Growth factor

Neurotrophins such as brain-derived neurotrophic factor (BDNF) are thought to be transferred from post- to presynaptic neurons and to be involved in the formation and plasticity of neural circuits. However, direct evidence for a transneuronal transfer of BDNF and its relation to neuronal activity re...