Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease

• Published in: Gut pathogens Vol. 13; no. 1; p. 13
• Main Authors: Hu, Shijia, Png, Eileen, Gowans, Michelle, Ong, David E. H., de Sessions, Paola Florez, Song, Jie, Nagarajan, Niranjan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.02.2021; BioMed Central; BMC
• Subjects: Abundance; Analysis; Arginine; Biosynthesis; Colonization; Crohn's disease; Diarrhea; Digestive system; Disease; Ethnicity; Feces; Fever; Gastrointestinal microbiome; Genomes; Genomics; Gut microbiota; Inflammation; Inflammatory bowel disease; Intestinal microflora; Isoprene; Medical research; Medicine, Experimental; Metagenomics; Microbiomes; Microbiota; Nucleotide sequence; Oral microbiome; Saliva; Taxonomy; Metagenomics; Gastrointestinal microbiome; Oral microbiome; Crohn’s disease

This study aims to characterize, the gut and oral microbiome in Asian subjects with Crohn's disease (CD) using whole genome shotgun sequencing, thereby allowing for strain-level comparison. A case-control study with age, sex and ethnicity matched healthy controls was conducted. CD subjects were...