Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: A multi-sample MRI study

• Published in: NeuroImage (Orlando, Fla.) Vol. 47; no. 4; pp. 1545 - 1557
• Main Authors: Westlye, Lars T., Walhovd, Kristine B., Dale, Anders M., Espeseth, Thomas, Reinvang, Ivar, Raz, Naftali, Agartz, Ingrid, Greve, Douglas N., Fischl, Bruce, Fjell, Anders M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2009; Elsevier Limited
• Subjects: Adult; Aging; Aging - pathology; Algorithms; Alzheimer Disease - pathology; Alzheimer's disease; Automation; Cerebral Cortex - pathology; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Magnetic Resonance Imaging - methods; Male; Middle Aged; Older people; Reproducibility of Results; Scanners; Sensitivity and Specificity; Studies; Young Adult

MRI-based estimates of cerebral morphometric properties, e.g. cortical thickness, are pivotal to studies of normal and pathological brain changes. These measures are based on automated or manual segmentation procedures, which utilize the tissue contrast between gray and white matter on T1-weighted M...