Risks and safety of pandemic h1n1 influenza vaccine in pregnancy: Birth defects, spontaneous abortion, preterm delivery, and small for gestational age infants

• Published in: Vaccine Vol. 31; no. 44; pp. 5026 - 5032
• Main Authors: Chambers, Christina D., Johnson, Diana, Xu, Ronghui, Luo, Yunjun, Louik, Carol, Mitchell, Allen A., Schatz, Michael, Jones, Kenneth L.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 17.10.2013; Elsevier; Elsevier Limited
• Subjects: Abortion; abortion (animals); Abortion, Spontaneous - epidemiology; Adult; Allergy and Immunology; Applied microbiology; Biological and medical sciences; Birth defects; Canada; cohort studies; confidence interval; congenital abnormalities; Congenital Abnormalities - epidemiology; Epidemiological Monitoring; Exposure; Female; Fetuses; Fundamental and applied biological sciences. Psychology; gestational age; Humans; Immunization; Infant, Newborn; Infant, Small for Gestational Age; Infants; influenza; Influenza A Virus, H1N1 Subtype; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza, Human - prevention & control; Interviews; Microbiology; Miscellaneous; pandemic; Pandemic H1N1 influenza vaccination; Pandemics; Pregnancy; Premature Birth - epidemiology; Preterm delivery; Prospective Studies; Risk; Risk assessment; Safety; Small for gestational age; Spontaneous abortion; Studies; Swine flu; United States; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virology; women; Canada; United States; United States > US; Pregnancy; Birth defects; Pandemic H1N1 influenza vaccination; Small for gestational age; Spontaneous abortion; Preterm delivery; Human; Intrauterine growth retardation; Pregnancy disorders; Vaccination; Premature delivery; Orthomyxoviridae; Infant; Vaccine; Abortion; Virus; Fetal diseases; Influenzavirus A; Prematurity; Influenza A virus

•Information is needed on safety of pandemic H1N1 influenza vaccines in pregnancy.•1032 exposed pregnant women were followed to pregnancy outcome, 2009–2012.•No increases in birth defects, spontaneous abortion or growth restriction were seen.•Vaccinated women on average delivered 3 days earlier than...