Hypoxia induces alterations in tRNA modifications involved in translational control

• Published in: BMC biology Vol. 21; no. 1; pp. 39 - 18
• Main Authors: Guo, Huanping, Xia, Lin, Wang, Wei, Xu, Wei, Shen, Xipeng, Wu, Xiao, He, Tong, Jiang, Xuelin, Xu, Yinying, Zhao, Pan, Tan, Dongmei, Zhang, Xi, Zhang, Yunfang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.02.2023; BioMed Central; BMC
• Subjects: Adaptation; Adaptation (Physiology); Altitude; Animal tissues; Animals; Cell proliferation; Chromatography, Liquid; Development and progression; DNA methylation; Edema; Enrichment; Environmental aspects; Enzymes; Epigenetics; Exposure; Fragments; Gene expression; Genes; Genetic aspects; Genetic translation; Health aspects; Heart; High altitude; High-altitude environments; Hypobaric hypoxia; Hypoxia; Hypoxia - genetics; Male; Metabolism; Mice; Molecular modelling; Peripheral blood; Physiological aspects; Physiological research; Physiology; Protein biosynthesis; Protein synthesis; Proteins; Reduction; Ribonuclease; Ribonuclease, Pancreatic; Ribonucleic acid; RNA; RNA modification; RNA modifications; RNA processing; RNA, Transfer - genetics; Structure; Tandem Mass Spectrometry; Transcriptomes; Transfection; Transfer RNA; tRNA; tsRNA; China; Hypobaric hypoxia; tRNA; RNA modifications; tsRNA

Adaptation to high-altitude hypobaric hypoxia has been shown to require a set of physiological traits enabled by an associated set of genetic modifications, as well as transcriptome regulation. These lead to both lifetime adaptation of individuals to hypoxia at high altitudes and generational evolut...