What is the function of receptor and membrane endocytosis at the postsynaptic neuron?

• Published in: Proceedings of the Royal Society. B, Biological sciences Vol. 267; no. 1450; pp. 1363 - 1367
• Main Author: Smythies, John
• Format: Journal Article
• Language: English
• Published: England The Royal Society 07.07.2000
• Subjects: Alzheimers disease; Animals; Cell Membrane - physiology; Cell membranes; Endocytosis; Endosomes; G-Protein-Linked Receptors; Humans; Internalization; Membrane Recycling; Molecules; Neurons; Neurons - physiology; Neuroscience; PI-3 kinase; Receptors; Receptors, Cell Surface - physiology; Receptors, G-Protein-Coupled; Recycling; Saccharomyces cerevisiae Proteins; Synapses; Synaptic Plasticity; Synaptic Scaling
• ISSN: 0962-8452; 1471-2954
• DOI: 10.1098/rspb.2000.1151

This paper explores the implications of certain new developments in cell biology upon neuroscience. Until recently it was thought that neurotransmitters and neuromodulators had only one function, which was to stimulate their specific receptors at the cell surface. From here on, all activity was supposed to be effected by postsynaptic cascades. The discovery that membrane components, particularly G-proteinlinked receptors, are not static but are subject to a massive and complex process of continual endocytosis, processing in the endosome system and recycling back to the external membrane, raises the question of its functional significance. In addition, it has been found that many neuromodulators such as polypeptides have their main locus of action inside the postsynaptic neuron. This review covers the role of the endocytic mechanism on receptor desensitization and resensitization, synaptic reorganization and plasticity, synaptic scaling and the possible repair of oxidative damage. The possible involvement of this system in Alzheimer's disease is discussed.