A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis

• Published in: PLoS genetics Vol. 7; no. 4; p. e1002058
• Main Authors: Bharucha, Nike, Chabrier-Rosello, Yeissa, Xu, Tao, Johnson, Cole, Sobczynski, Sarah, Song, Qingxuan, Dobry, Craig J, Eckwahl, Matthew J, Anderson, Christopher P, Benjamin, Andrew J, Kumar, Anju, Krysan, Damian J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2011; Public Library of Science (PLoS)
• Subjects: Biology; Candida albicans; Candida albicans - genetics; Candida albicans - growth & development; Cell Nucleus - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene Expression Regulation, Fungal; Genes; Genes, Fungal; Genetic aspects; Genetics; Genomic Library; Haploinsufficiency; Heterozygote; Hyphae - growth & development; Hyphae - metabolism; Infections; Kinases; Medicine; Morphogenesis; Mutagenesis, Insertional; Mutation; Physiological aspects; Promoter Regions, Genetic; Protein kinases; Proteins; Signal Transduction; Transcription Factors - genetics; Transcription Factors - metabolism; United States

The morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways. How these pathways interact to orchestrate morphogenesis, however, has not been as well characterized. To address this question and to ident...