Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study

• Published in: Nutrition journal Vol. 15; no. 1; p. 14
• Main Authors: Lugo, James P., Saiyed, Zainulabedin M., Lane, Nancy E.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.01.2016; BioMed Central
• Subjects: Adult; Aged; Analysis; Biomarkers - blood; Body Mass Index; Body Weight; C-Reactive Protein - metabolism; Care and treatment; cartilage; Cartilage Oligomeric Matrix Protein - blood; chickens; chondroitin sulfate; Collagen; Collagen Type II - administration & dosage; covariance; Dietary Supplements; Double-Blind Method; Female; glucosamine; Health aspects; Humans; Interleukin-6 - blood; Male; Matrix Metalloproteinase 3 - blood; Middle Aged; Nutrition; Ontario; Osteoarthritis; Osteoarthritis, Knee - drug therapy; pain; Pain Measurement; Placebo effect; placebos; Safety and security measures; statistical models; sternum; Treatment Outcome; volunteers; Ontario

Undenatured type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage. The purpose of this study was to evaluate the efficacy and tolerability of UC-II for knee osteoarthritis (OA) pain and associated symptoms compared to placebo and to glucosamine hydrochloride plu...