Muscular exercise can cause highly pathological liver function tests in healthy men

• Published in: British journal of clinical pharmacology Vol. 65; no. 2; pp. 253 - 259
• Main Authors: Pettersson, Jonas, Hindorf, Ulf, Persson, Paula, Bengtsson, Thomas, Malmqvist, Ulf, Werkström, Viktoria, Ekelund, Mats
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2008; Blackwell Science Inc
• Subjects: Adolescent; Adult; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Basic Medicine; Clinical Enzyme Tests - trends; clinical trials; Exercise - physiology; Farmakologi och toxikologi; gamma-Glutamyltransferase - blood; Humans; Liver - metabolism; Liver - pathology; liver function tests; Liver Function Tests - trends; Läkemedelskemi; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Methods in Clinical Pharmacology; Middle Aged; Muscle, Skeletal - metabolism; Pharmacology and Toxicology; physical exercise; Time Factors; Weight Lifting - physiology

What is already known about this subject • The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals. • Physical exercise can result in transient elevations of liver function tests...