Damage to the Fronto-Polar Cortex Is Associated with Impaired Multitasking

A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally...

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Published inPloS one Vol. 3; no. 9; p. e3227
Main Authors Dreher, Jean-Claude, Koechlin, Etienne, Tierney, Michael, Grafman, Jordan
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 16.09.2008
Public Library of Science (PLoS)
Subjects
Adult
Age
Aged
Behavior disorders
Brain
Brain - anatomy & histology
Brain - pathology
Brain architecture
Brain Injuries - physiopathology
Brain Mapping
Brodmann's area
Case-Control Studies
Cerebral Cortex
Cognition
Cognition & reasoning
Cognition Disorders - physiopathology
Cognitive ability
Cognitive science
Cognitive Sciences
Conventions
Drug abuse
Female
Functional morphology
Human performance
Humans
Hypotheses
Life Sciences
Male
Medical imaging
Memory
Mental Health/Cognitive Neurology
Middle Aged
Multitasking
Neuroimaging
Neurological Disorders
Neurology
Neurons and Cognition
Neuropsychological Tests
Neuroscience
Neuroscience/Cognitive Neuroscience
Neuroscience/Psychology
Neurosciences
Patients
Prefrontal cortex
Stroke
Studies
Tomography
Traumatic brain injury
Trends
France
United States > US
Maryland
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0003227

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Abstract A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities. These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
AbstractList A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
Background A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. Principal Findings Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities. Conclusion/Significance These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals.Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities.These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities. These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
Background A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals. Principal Findings Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities. Conclusion/Significance These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
Background: A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals.Principal Findings:Here we show that the extent of damage to the fronto-polar cortex predicts impairment in themanagement of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasksthat require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial forcomplex human cognitive abilities.Conclusion/Significance:These results provide important new insights concerning the cerebral basis of complex humancognition such as planning and multitasking.
A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals.BACKGROUNDA major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular importance to the cognitive capacities that are uniquely human is the fronto-polar cortex (Brodmann's area 10), which is disproportionally larger in humans relative to the rest of the brain than it is in the ape's brain. The specific function of this brain region remains poorly understood, but recent neuroimaging studies have proposed that it may hold goals in mind while exploring and processing secondary goals.Here we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities.PRINCIPAL FINDINGSHere we show that the extent of damage to the fronto-polar cortex predicts impairment in the management of multiple goals. This result reveals that the integrity of the fronto-polar cortex is necessary to perform tasks that require subjects to maintain a primary goal in mind while processing secondary goals, an ability which is crucial for complex human cognitive abilities.These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.CONCLUSION/SIGNIFICANCEThese results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
Audience Academic
Author Grafman, Jordan
Koechlin, Etienne
Dreher, Jean-Claude
Tierney, Michael
AuthorAffiliation University of California San Diego, United States of America
Cognitive Neuroscience Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
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  givenname: Jordan
  surname: Grafman
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/18795100$$D View this record in MEDLINE/PubMed
https://hal.science/hal-02341228$$DView record in HAL
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ContentType Journal Article
Copyright COPYRIGHT 2008 Public Library of Science
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Distributed under a Creative Commons Attribution 4.0 International License
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 2008
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– notice: This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
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Current address: INSERM U742, Paris VI University, Paris, France
Conceived and designed the experiments: JCD EK JG. Performed the experiments: JCD MT. Analyzed the data: JCD. Contributed reagents/materials/analysis tools: JCD. Wrote the paper: JCD JG.
Current address: Cognitive Neuroscience Center, ‘Reward and decision making’ team, CNRS UMR 5229, Lyon, France
ORCID 0000-0002-2157-1529
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Snippet A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of particular...
Background A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of...
Background: A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of...
Background A major question in understanding the functional organization of the brain is to delineate the functional divisions of the prefrontal cortex. Of...
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Prefrontal cortex
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Studies
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Title Damage to the Fronto-Polar Cortex Is Associated with Impaired Multitasking
URI https://www.ncbi.nlm.nih.gov/pubmed/18795100
https://www.proquest.com/docview/1312438278
https://www.proquest.com/docview/69550395
https://hal.science/hal-02341228
https://pubmed.ncbi.nlm.nih.gov/PMC2528949
https://doaj.org/article/fd72597b6ce74e1894efc82e527924ed
http://dx.doi.org/10.1371/journal.pone.0003227
Volume 3
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