Self-healing hybrid nanocomposites consisting of bisphosphonated hyaluronan and calcium phosphate nanoparticles
Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we...
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| Published in | Biomaterials Vol. 35; no. 25; pp. 6918 - 6929 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.08.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. |
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| AbstractList | Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds.Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. Abstract Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. |
| Author | Huysmans, Marie C. Yang, Xia Alghamdi, Hamdan S. Hilborn, Jöns van den Beucken, Jeroen J.J.P. Ossipov, Dmitri Leeuwenburgh, Sander C.G. Jansen, John A. Nejadnik, M. Reza Bongio, Matilde |
| Author_xml | – sequence: 1 givenname: M. Reza surname: Nejadnik fullname: Nejadnik, M. Reza organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 2 givenname: Xia surname: Yang fullname: Yang, Xia organization: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden – sequence: 3 givenname: Matilde surname: Bongio fullname: Bongio, Matilde organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 4 givenname: Hamdan S. surname: Alghamdi fullname: Alghamdi, Hamdan S. organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 5 givenname: Jeroen J.J.P. surname: van den Beucken fullname: van den Beucken, Jeroen J.J.P. organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 6 givenname: Marie C. surname: Huysmans fullname: Huysmans, Marie C. organization: Department of Preventive and Restorative Dentistry, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 7 givenname: John A. surname: Jansen fullname: Jansen, John A. organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands – sequence: 8 givenname: Jöns surname: Hilborn fullname: Hilborn, Jöns organization: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden – sequence: 9 givenname: Dmitri surname: Ossipov fullname: Ossipov, Dmitri email: dmitri.ossipov@kemi.uu.se organization: Department of Materials Chemistry, Angstrom Laboratory, A Science for Life Laboratory, Uppsala University, SE 75121 Uppsala, Sweden – sequence: 10 givenname: Sander C.G. surname: Leeuwenburgh fullname: Leeuwenburgh, Sander C.G. email: sander.leeuwenburgh@radboudumc.nl organization: Department of Biomaterials, Radboud University Medical Center, 6525EX Nijmegen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24862440$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224369$$DView record from Swedish Publication Index |
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| Keywords | Organic-inorganic nanocomposites Hydrogels Bone regeneration Reversible bonds Self-healing materials |
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| Snippet | Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding... Abstract Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the... |
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| SubjectTerms | Advanced Basic Science Animals Biocompatible Materials - chemistry biodegradability Biomedical materials Bone and Bones - drug effects Bone and Bones - metabolism Bone Development - drug effects Bone regeneration Bones Calcium phosphate Calcium Phosphates - chemistry Cohesion crosslinking Dentistry Diphosphonates - chemistry Durapatite - chemistry enamel energy hyaluronic acid Hyaluronic Acid - chemistry Hydrogels Hydrogels - chemistry hydroxyapatite in vivo studies Integrity Male Materials Testing Nanocomposites Nanocomposites - chemistry Nanoparticles Nanoparticles - chemistry Organic-inorganic nanocomposites Rats Rats, Wistar Reversible bonds Self-healing materials Surface Properties Surgical implants |
| Title | Self-healing hybrid nanocomposites consisting of bisphosphonated hyaluronan and calcium phosphate nanoparticles |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0142961214005468 https://www.clinicalkey.es/playcontent/1-s2.0-S0142961214005468 https://dx.doi.org/10.1016/j.biomaterials.2014.05.003 https://www.ncbi.nlm.nih.gov/pubmed/24862440 https://www.proquest.com/docview/1534472590 https://www.proquest.com/docview/1627972556 https://www.proquest.com/docview/1642241012 https://www.proquest.com/docview/2101317628 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224369 |
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