SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI

• Published in: NeuroImage (Orlando, Fla.) Vol. 215; p. 116835
• Main Authors: Palombo, Marco, Ianus, Andrada, Guerreri, Michele, Nunes, Daniel, Alexander, Daniel C., Shemesh, Noam, Zhang, Hui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.07.2020; Elsevier Limited; Academic Press; Elsevier
• Subjects: Adult; Animals; Axons; Brain; Brain - cytology; Brain - diagnostic imaging; Brain - physiology; Brain architecture; Brain mapping; Cell body; Cell Body - physiology; Diffusion Magnetic Resonance Imaging - methods; Female; Glia; Humans; Magnetic resonance imaging; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Nervous system; Neurites - physiology; Neuroimaging; Simulation

This work introduces a compartment-based model for apparent cell body (namely soma) and neurite density imaging (SANDI) using non-invasive diffusion-weighted MRI (DW-MRI). The existing conjecture in brain microstructure imaging through DW-MRI presents water diffusion in white (WM) and gray (GM) matt...