Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS

• Published in: Analytical and bioanalytical chemistry Vol. 391; no. 6; pp. 2309 - 2322
• Main Authors: Stolker, A.A.M, Rutgers, P, Oosterink, J.E, Lasaroms, J.J.P, Peters, R.J.B, Rhijn, J.A. van, Nielen, M.W.F
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2008
• Subjects: Analytical Chemistry; Animals; antibiotic residues; benzimidazoles; Biochemistry; centrifugation; Characterization and Evaluation of Materials; Chemical Precipitation; Chemistry; Chemistry and Materials Science; Chromatography, High Pressure Liquid; flight mass-spectrometry; Food Science; growth-promoting agents; ionophores; ions; Laboratory Medicine; macrolides; mass spectrometry; maximum residue limits; milk; Milk - chemistry; Monitoring/Environmental Analysis; muscle; nitroimidazoles; nonsteroidal anti-inflammatory agents; Original Paper; penicillins; pyrimidines; quinolones; raw milk; residue analysis; screening; solid phase extraction; Solid Phase Microextraction; strategies; sulfonamides; Tandem Mass Spectrometry - methods; Tandem Mass Spectrometry - standards; tranquilizers; ultra-performance liquid chromatography; urine; veterinary drugs; Veterinary Drugs - analysis; Validation; Full scan; 2002/657/EC; Multi-class; Time-of-flight; Multi-residue

Ultra-performance liquid chromatography combined with time-of-flight mass spectrometry (UPLC–ToF-MS) has been used for screening and quantification of more than 100 veterinary drugs in milk. The veterinary drugs represent different classes including benzimidazoles, macrolides, penicillins, quinolone...