Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment

Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic...

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Published inTrends in biotechnology (Regular ed.) Vol. 27; no. 6; pp. 350 - 358
Main Authors Phan, John H, Moffitt, Richard A, Stokes, Todd H, Liu, Jian, Young, Andrew N, Nie, Shuming, Wang, May D
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Ltd 01.06.2009
[London]: Elsevier Science
Cell Press
Elsevier Limited
Subjects
Antineoplastic Protocols
Behavior
Bioinformatics
Biological and medical sciences
Biomarkers
Biomarkers, Tumor
Biotechnology
Cancer
Cancer therapies
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - drug therapy
Carcinoma, Renal Cell - therapy
Computational Biology
Convergence
Data processing
Disease
Disease detection
Fundamental and applied biological sciences. Psychology
Gene expression
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Internal Medicine
Kidney Neoplasms - diagnosis
Kidney Neoplasms - drug therapy
Kidney Neoplasms - therapy
Kinases
Knowledge Bases
Miscellaneous
Nanoparticles
Nanotechnology
Nanotechnology - methods
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - therapy
Patients
Polypeptides
Proteins
Quantum dots
Technological change
Tumors
Treatment
Biological marker
Review
Malignant tumor
Personalized medicine
Bioinformatics
Predictive medicine
Nanotechnology
Cancer
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Abstract Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.
AbstractList Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which disease detection, diagnosis and therapy are tailored to each individual's molecular profile) and predictive medicine (in which genetic and molecular information is used to predict disease development, progression and clinical outcome). Here, we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, in addition to the prospects for and challenges involved in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.
Recent advances in biomarker discovery, biocomputing, and nanotechnology have raised new opportunities for the emerging field of personalized medicine in which disease detection, diagnosis, and therapy are tailored to each individual’s molecular profile, and also for predictive medicine that uses genetic/molecular information to predict disease development, progression, and clinical outcome. Here we discuss advanced biocomputing tools for cancer biomarker discovery and multiplexed nanoparticle probes for cancer biomarker profiling, together with prospects and challenges in correlating biomolecular signatures with clinical outcome. This bio-nano-info convergence holds great promise for molecular diagnosis and individualized therapy of cancer and other human diseases.
Author Moffitt, Richard A
Nie, Shuming
Wang, May D
Liu, Jian
Young, Andrew N
Phan, John H
Stokes, Todd H
AuthorAffiliation 1 Departments of Biomedical Engineering and Electrical and Computer Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, UA Whitaker Building 4106, Atlanta, GA 30332, USA
2 Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322, USA
3 Department of Pathology and Laboratory Medicine, Emory University School of Medicine and the Grady Memorial Hospital, Atlanta, GA 30322, USA
AuthorAffiliation_xml – name: 3 Department of Pathology and Laboratory Medicine, Emory University School of Medicine and the Grady Memorial Hospital, Atlanta, GA 30322, USA
– name: 1 Departments of Biomedical Engineering and Electrical and Computer Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, UA Whitaker Building 4106, Atlanta, GA 30332, USA
– name: 2 Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322, USA
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fao_agris_US201301633430
elsevier_sciencedirect_doi_10_1016_j_tibtech_2009_02_010
elsevier_clinicalkeyesjournals_1_s2_0_S0167779909000730
PublicationCentury 2000
PublicationDate 2009-06-01
PublicationDateYYYYMMDD 2009-06-01
PublicationDate_xml – month: 06
  year: 2009
  text: 2009-06-01
  day: 01
PublicationDecade 2000
PublicationPlace Cambridge, MA
PublicationPlace_xml – name: Cambridge, MA
– name: England
– name: Oxford
PublicationTitle Trends in biotechnology (Regular ed.)
PublicationTitleAlternate Trends Biotechnol
PublicationYear 2009
Publisher Elsevier Ltd
[London]: Elsevier Science
Cell Press
Elsevier Limited
Publisher_xml – name: Elsevier Ltd
– name: [London]: Elsevier Science
– name: Cell Press
– name: Elsevier Limited
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Snippet Recent advances in biomarker discovery, biocomputing and nanotechnology have raised new opportunities in the emerging fields of personalized medicine (in which...
Recent advances in biomarker discovery, biocomputing, and nanotechnology have raised new opportunities for the emerging field of personalized medicine in which...
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SubjectTerms Antineoplastic Protocols
Behavior
Bioinformatics
Biological and medical sciences
Biomarkers
Biomarkers, Tumor
Biotechnology
Cancer
Cancer therapies
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - drug therapy
Carcinoma, Renal Cell - therapy
Computational Biology
Convergence
Data processing
Disease
Disease detection
Fundamental and applied biological sciences. Psychology
Gene expression
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Internal Medicine
Kidney Neoplasms - diagnosis
Kidney Neoplasms - drug therapy
Kidney Neoplasms - therapy
Kinases
Knowledge Bases
Miscellaneous
Nanoparticles
Nanotechnology
Nanotechnology - methods
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - therapy
Patients
Polypeptides
Proteins
Quantum dots
Technological change
Tumors
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Title Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment
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