Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance

• Published in: Journal of allergy and clinical immunology Vol. 131; no. 1; pp. 180 - 186.e3
• Main Authors: Ford, Lara S., Bloom, Katherine A., Nowak-Węgrzyn, Anna H., Shreffler, Wayne G., Masilamani, Madhan, Sampson, Hugh A.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.01.2013; Elsevier; Elsevier Limited
• Subjects: Adolescent; Age; Allergic diseases; Allergies; Allergy and Immunology; Animals; baked; basophil activation; basophils; Basophils - immunology; Biological and medical sciences; biomarker; Biomarkers; blood serum; casein; Cattle; Child; Child, Preschool; children; Cow's milk allergy; Digestive allergic diseases; extensively heated; Female; flow cytometry; Food; Food allergies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immune Tolerance; immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; immunomodulation; Immunopathology; Immunotherapy; Male; Mast Cells - immunology; Medical sciences; Milk; Milk - adverse effects; milk allergy; Milk Hypersensitivity - diagnosis; Milk Hypersensitivity - immunology; Patients; phenotype; Pizza; prognosis; Proteins; Quality of life; ROC Curve; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin Tests; tolerance; immunomodulation; basophil activation; SPT; immunotherapy; extensively heated; baked; Cow's milk allergy; biomarker; tolerance; Skin prick test; Food allergy; Immunopathology; Temperature; Immunoglobulins; Immunomodulation; Granulocyte; Biological marker; Tolerance; Environmental factor; Activation; Basophil; Protein Bak; Heat; Immunology; Reactivity; Treatment; Immunotherapy; Digestive diseases; Cow milk

In our previous study about 75% of children with cow's milk allergy tolerated baked milk products, which improved their prognosis and quality of life. We sought to identify biomarkers of varying degrees of clinical tolerance among a cohort of children with cow's milk allergy. One hundred t...