Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria

• Published in: PLoS biology Vol. 21; no. 8; p. e3002186
• Main Authors: Saathoff, Mareike, Kosol, Simone, Semmler, Torsten, Tedin, Karsten, Dimos, Nicole, Kupke, Johannes, Seidel, Maria, Ghazisaeedi, Fereshteh, Jonske, Micela Condor, Wolf, Silver A., Kuropka, Benno, Czyszczoń, Wojciech, Ghilarov, Dmitry, Grätz, Stefan, Heddle, Jonathan G., Loll, Bernhard, Süssmuth, Roderich D., Fulde, Marcus
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.08.2023; Public Library of Science (PLoS)
• Subjects: Amplification; Antibiotic resistance; Antibiotics; Antimicrobial peptides; Bacteria; Bactericidal activity; Binding; Biology and Life Sciences; Conserved sequence; Control; Copy number; Crystallography; Dosage and administration; Drug resistance in microorganisms; E coli; Evolution; Gene amplification; Gene sequencing; Genetic aspects; Genomes; Gram-negative bacteria; Gram-positive bacteria; Grooves; Health aspects; Kinases; Medicine and Health Sciences; Molecular docking; Mutation; Peptides; Phylogeny; Physical Sciences; Proteins; Proteomics; Research and Analysis Methods; X-ray crystallography; Germany

Antibiotic resistance is a continuously increasing concern for public healthcare. Understanding resistance mechanisms and their emergence is crucial for the development of new antibiotics and their effective use. The peptide antibiotic albicidin is such a promising candidate that, as a gyrase poison...