Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation

• Published in: PLoS biology Vol. 22; no. 4; p. e3002605
• Main Authors: Wei, Kevin H-C., Chatla, Kamalakar, Bachtrog, Doris
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.04.2024; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Cell division; Chromosomes; Dosage; Dosage compensation; Drosophila; Evolution; Females; Fruit flies; Gene dosage; Gene sequencing; Genes; Inactivation; Insects; Males; Medicine and Health Sciences; Meiosis; Methods; Molecular modelling; Natural history; Physiological aspects; Regulatory mechanisms (biology); Ribonucleic acid; RNA; RNA sequencing; Sex; Sex chromosomes; Sex linkage; Somatic chromosomes; Sperm; Spermatogenesis; Testes; X chromosomes; Y chromosomes; Canada

Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific such as dosage compensation (DC) and meiotic sex chromosome inactivation (MSCI). The molecular mechanisms and evolutionary forces driving these unique transcriptional...