Role of aneuploid circulating tumor cells and CD31+ circulating tumor endothelial cells in predicting and monitoring anti‐angiogenic therapy efficacy in advanced NSCLC

• Published in: Molecular Oncology Vol. 15; no. 11; pp. 2891 - 2909
• Main Authors: Zhang, Tongmei, Zhang, Lina, Gao, Yuan, Wang, Ying, Liu, Yanxia, Zhang, Hongmei, Wang, Qunhui, Hu, Fanbin, Li, Jie, Tan, Jinjing, Wang, Daisy Dandan, Gires, Olivier, Lin, Peter Ping, Li, Baolan
• Format: Journal Article
• Language: English
• Published: United States Wiley 01.11.2021; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Aneuploidy; Angiogenesis; Bevacizumab; Biomarkers; Biomarkers, Tumor; Breast cancer; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - pathology; Cell adhesion molecules; Chemotherapy; Cloning; EMT and EndoMT; Endothelial cells; Endothelial Cells - metabolism; Endothelium; EpCAM and vimentin; Epithelial cells; Gene expression; Humans; Laboratories; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - pathology; Medical prognosis; Mesenchyme; Metastasis; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Neoplastic Cells, Circulating - pathology; Neovascularization; Non-small cell lung carcinoma; Patients; prognosticators; RC254-282; Risk factors; SE‐iFISH; Small cell lung carcinoma; therapy efficacy; Tumor cells; Tumorigenesis; Tumors; Vascular endothelial growth factor; Vimentin; Beijing China; United States > US; China; Germany; EpCAM and vimentin; bevacizumab; therapy efficacy; SE-iFISH; EMT and EndoMT; prognosticators
• ISSN: 1574-7891; 1878-0261; 1878-0261
• DOI: 10.1002/1878-0261.13092

Prognosticating the efficacy of anti‐angiogenic therapy through longitudinal monitoring and early detection of treatment resistance in cancer patients remain highly challenging. In this study, co‐detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulatin...