A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus - Fitzsimmons, William J.; Woods, Robert J.; McCrone, John T.; Woodman, Andrew; Arnold, Jamie J.; Yennawar, Madhumita; Evans, Richard; Cameron, Craig E.; Lauring, Adam S. (PLoS biology, 2018)
Keywords: Adaptability; Attenuation; Biochemistry; Biological evolution; Biology and Life Sciences; Compensation; Defects; Deoxyribonucleic acid; DNA; Evolution; Fidelity; Gene mutations; Genetic aspects; Genetic diversity; Genetic drift; Genomes; Health aspects; Immunology; Infectious diseases; Internal medicine; Medicine and Health Sciences; Molecular biology; Morbidity; Mutation; Mutation rates; Pathogenesis; Phenotypes; Polymerase chain reaction; Polypeptides; Proofreading; Proteins; Research and Analysis Methods; Reversion; Ribonucleic acid; RNA; RNA viruses; Supervision; Virulence; Virulence (Microbiology); Viruses; Ann Arbor Michigan; United States--US; Pennsylvania; Michigan