The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection

• Published in: PLoS biology Vol. 19; no. 9; p. e3001385
• Main Authors: Cappelletti, Monica, Presicce, Pietro, Feiyang, Ma, Senthamaraikannan, Paranthaman, Miller, Lisa A., Pellegrini, Matteo, Sim, Myung S., Jobe, Alan H., Divanovic, Senad, Way, Sing Sing, Chougnet, Claire A., Kallapur, Suhas G.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.09.2021; Public Library of Science (PLoS)
• Subjects: Amnion; Amniotic fluid; Animals; Biology and Life Sciences; Biomarkers; Chemotaxis; Cytokines; Decidua; Disease Models, Animal; E coli; Escherichia coli; Escherichia coli - pathogenicity; Escherichia coli Infections - complications; Escherichia coli Infections - immunology; Female; Fetuses; Flow cytometry; Gene sequencing; Health aspects; Homeostasis; Immune response; Immune system; Immunity; Infections; Infiltration; Inflammation; Interferon; Interleukin 6; Labor; Leukocytes (neutrophilic); Lipopolysaccharides; Lipopolysaccharides - toxicity; Macaca mulatta; Medicine and Health Sciences; Microorganisms; Neutrophils; Observations; Obstetric Labor, Premature - pathology; Pregnancy; Pregnancy Complications - immunology; Prostaglandins; Rhesus monkey; Sepsis; SUMO protein; United States

Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL. To define the triggers for PTL, we developed rh...