Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

• Published in: BMC cancer Vol. 15; no. 1; p. 958
• Main Authors: Lin, Chia-Hung, Chang, Ching-Yao, Lee, Kuan-Rong, Lin, Hui-Ju, Chen, Ter-Hsin, Wan, Lei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.12.2015; BioMed Central
• Subjects: Analysis; Antineoplastic Agents, Phytogenic - pharmacology; Apigenin - pharmacology; Apoptosis - drug effects; Bioflavonoids; Blotting, Western; Breast cancer; Breast Neoplasms - pathology; Care and treatment; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cellular signal transduction; Complications and side effects; Development and progression; Female; Flavones; Flavones - pharmacology; Flavonoids; Flow Cytometry; Forkhead Box Protein O3; Forkhead Transcription Factors - metabolism; Humans; Influence; Luteolin - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction - drug effects

Flavones found in plants display various biological activities, including anti-allergic, anti-viral, anti-inflammatory, anti-oxidation, and anti-tumor effects. In this study, we investigated the anti-tumor effects of flavone, apigenin and luteolin on human breast cancer cells. The anti-cancer activi...