The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

• Published in: PLoS biology Vol. 16; no. 8; p. e2006443
• Main Authors: Chan, Jia Pei, Wong, Bernice H., Chin, Cheen Fei, Galam, Dwight L. A., Foo, Juat Chin, Wong, Loo Chin, Ghosh, Sujoy, Wenk, Markus R., Cazenave-Gassiot, Amaury, Silver, David L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.08.2018; Public Library of Science (PLoS)
• Subjects: Accretion; Animal models; Animals; Biochemistry; Biological control systems; Biological Transport; Biology and Life Sciences; Biosynthesis; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Brain - embryology; Brain - metabolism; Brain research; Carrier proteins; Carrier Proteins - metabolism; Cholesterol; Clonal deletion; Deposition; Disease Models, Animal; Docosahexaenoic acid; Docosahexaenoic Acids - metabolism; Endothelium; Endothelium, Vascular - metabolism; Esterification; Fatty acids; Feedback loops; Female; Gene expression; Lipids; Lipogenesis; Lipogenesis - genetics; Lipogenesis - physiology; Lysophosphatidylcholine; Lysophosphatidylcholines - metabolism; Male; Medical schools; Medicine and Health Sciences; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Membrane Transport Proteins - physiology; Metabolic disorders; Mice; Mice, Inbred C57BL; Microcephaly; Neural stem cells; Omega-3 fatty acids; Phospholipids; Physiological aspects; Polyunsaturated fatty acids; Proteins; Research and Analysis Methods; Saturation; Stem cell transplantation; Stem cells; Sterol regulatory element-binding protein; Sterols; Supervision; Singapore

Brain development requires a massive increase in brain lipogenesis and accretion of the essential omega-3 fatty acid docosahexaenoic acid (DHA). Brain acquisition of DHA is primarily mediated by the transporter Major Facilitator Superfamily Domain containing 2a (Mfsd2a) expressed in the endothelium...